منابع مشابه
Busulfan bioavailability.
Busulfan is widely used as a component of the myeloablative therapy in bone marrow transplantation. Recent studies have shown that the drug disposition is altered in children and is associated with less therapeutic effectiveness, lower toxicities, and higher rates of engraftment failure. We have evaluated the bioavailability of the drug in two groups of patients: eight children between 1.5 and ...
متن کاملBusulfan disposition in children.
Children receive busulfan orally as part of myeloablative therapy before bone marrow transplantation for malignant and nonmalignant conditions. Children have been reported to have a low incidence of severe toxicity and significant rates of failure to achieve full engraftment. We evaluated the disposition of busulfan in children between 2 months and 3.6 years of age with lysosomal storage diseas...
متن کاملBusulfan therapy in myeloid metaplasia.
By NOBORU Oism, SCOTT N. SWISHER AND STANLEY B. Tu0UP B USULFAN#{176} ( i,4-dirnethanesulphon loxybutanc ) is a radiomimetic agent which appears to inhibit cellular metabolism through its ability to alkylate nuclcoproteins.11 Cells undergoing division seem particularly susceptible to the action of busulfan. Since it was synthesized by Haddow and Timmis,4 husulfan has been successfully used in t...
متن کاملWhich dose of busulfan is best?
A 24-year-old woman with advanced Hodgkin disease received the standard dosing protocol for busulfan/cyclophosphamide before autologous hematopoietic stem cell transplantation (HSCT) 4 from a matched unrelated donor. The target area under the plasma concentration vs time curve (AUC) for busulfan was set at 950 μmol · L -1 · min -1 , near the low end of the therapeutic interval of 900–1350 μmol ...
متن کاملChronopharmacology of High-Dose Busulfan in Children1
In bone marrow transplantation, high-dose busulfan is given p.o., usu ally every 6 h over 4 consecutive days. Since this repeated administration might alter busulfan disposition, fluctuations in busulfan plasma levels were studied over the 4-day treatment period in 21 children (median age, 5 years) with malignant solid tumors. In addition, urinary excretion of unchanged busulfan was measured ev...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-01622-5